张磊

　　

1．基本信息

张磊，助理研究员，硕士生导师。2011年毕业于西北民族大学，获学士学位；2014毕业于西北农林科技大学，获硕士学位；2017年毕业于西北农林科技大学，获博士学位；2018年起，加入动物科技学院羊产业技术创新团队。现兼任国际奶羊产业协会专业技术委员会委员，陕西省奶山羊产业技术创新与产业发展战略联盟岗位专家，甘肃元生中新奶绵羊产业研究院特聘专家。

2. 研究方向

羊遗传育种与繁殖。主要从事奶羊、肉羊生殖生理调控和分子育种的科研推广工作。

3. 主持项目

（1）CircRNA8074调控奶山羊容受性子宫内膜建立的分子机制，中国博士后科学基金会面上二等，8万元，2019.05-2020.12。

（2）CircRNA8074调控奶山羊子宫内膜细胞的分子机制研究，陕西省自然科学基金项目青年面上，3万元，2020.01-2021.12.

（3）吴起肉羊试验示范基地农业专家服务站建设项目，陕西省科学技术协会，3万元，2020.01-2020.12。

（4）甘肃元生技术咨询合作项目，企业技术服务，甘肃元生农牧科技有限公司，40万元，2019.01-2021.12。

（5）麟游县布尔羊现代农业产业发展，地方技术服务，麟游县财政，6万元，2020.01-2020.12。

（6）延安肉羊示范基地共建，校地合作，延安市人民政府，80万元，2019.01-2023.12。

（7）合作共建金昌奶绵羊试验示范基，校地合作，金昌市人民政府，30万元，2020.01-2024.12。

4.学术成果

近几年在羊子宫内膜容受性建立的表观调控研究方面积累了丰富的经验，相关研究成果在《Molecular Therapy - Nucleic Acids》、《BBA-Molecular Cell Research》、《Journal of Cellular Physiology》、《Reproduction, Fertility and Development》、《Animal Production Science》和《Reproduction in Domestic Animals》等期刊发表SCI论文20余篇；获批国家专利5项、软件著作权6项。

(1) Zhang L, Liu X, Che S, Cui J, Ma X, An X, Cao B*, Song Y*. Endometrial Epithelial Cell Apoptosis Is Inhibited by a ciR8073-miR181a-Neurotensis Pathway during Embryo Implantation. Molecular Therapy-Nucleic Acids, 2019, 14:262-273. doi: 10.1016/j.omtn.2018.12.005 (IF=" 7.032, Q1).

(2) Lei Zhang, Xiao-Rui Liu, Yu-Xuan Song, Jun-Ze Liu, Xing-Na Ma, Zhanqin Zhou, Bin-Yun Cao*. MiR-26a promoted endometrial epithelium cells (EECs) proliferation and induced stromal cells (ESCs) apoptosis via the PTEN-PI3K/AKT pathway in dairy goats. Journal of Cellular Physiology, 2018, 233(6):4688-4706 (IF= 5.546, Q1).

(3) Lei Zhang, Xiaorui Liu, Xingna Ma, Yuexia Liu, Sicheng Che, Jiuzeng Cui, Xiaopeng An, Binyun Cao*, Yuxuan Song*. Testin was regulated by circRNA3175-miR182 and inhibited endometrial epithelial cell apoptosis in pre-receptive endometrium of dairy goats. Journal of Cellular Physiology, 2018, 233(10):6965-6974 (IF=" 5.546, Q1).

(4) Liu X, Zhang L*, Liu Y, Cui J, Che S, An X, Song Y, Cao B*. Circ-8073 regulates CEP55 by sponging miR-449a to promote caprine endometrial epithelial cells proliferation via the PI3K/AKT/mTOR pathway. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2018, 1865(8):1130-1147. (并列通讯，IF= 4.651, Q1).

(5) Zhang L, Liu X, Che S, Cui J, Liu Y, An X, Cao B, Song Y*. CircRNA-9119 regulates the expression of prostaglandin-endoperoxide synthase 2 (PTGS2) by sponging miR-26a in the endometrial epithelial cells of dairy goat. Reproduction Fertility & Development, 2018, 9, doi: 10.1071/RD18074. (IF=" 2.105, Q1).

(6) Zhang Lei, Liu Xiaorui, Cui Jiuzeng, Che Sicheng, Liu Yuexia, An Xiaopeng, Cao Binyun*, Song Yuxuan*. LncRNA882 regulates leukemia inhibitory factor (LIF) by sponging miR-15b in the endometrial epithelium cells of dairy goat. Journal of Cellular Physiology, 2019, 234(4):4754-4767 (IF=" 5.546, Q1).

(7) Liu, XR, Zhang, L, Cui, JZ, Che, SC, Liu, YX, Zhang, Y, Cao, BY, Song, YX . The mRNA and lncRNA landscape of the non-pregnant endometrium during the oestrus cycle in dairy goat. Animal Production Science. 2019, 59(10)1803-1813. DOI: 10.1071/AN18426 (IF=" 1.275, Q2).

(8) Lei Zhang*, Fang Peng, Fangbai Yu, Lu Wan, Zhan-Qin Zhou*. Expression of ESR1, PRLR, GHR, and IGF1R in mammary glands of Hu sheep with four teats. Czech Journal of Animal Science, 2019, 64 (2): 49–58. DOI: 10.17221/3/2018-CJAS (IF=" 1.0085, Q3).

(9) Song, YX, Zhang, L, Liu, XR, Niu, MX, Cui, JZ, Che, SC, Liu, YX, An, XP, Cao, BY. Analyses of circRNA profiling during the development from pre-receptive to receptive phases in the goat endometrium. Journal of Animal Science and Biotechnology, 2019,  2019,10(03): 633-647. DOI: 10.1186/s40104-019-0339-4. (IF=" 3.441, Q1).

(10) Lei Zhang#, Xiao-Rui Liu#, Jun-Ze Liu, Yu-Xuan Song, Zhan-Qin Zhou, Bin-Yun Cao*, Xiaopeng An*. miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression. Plos one, 2017, 12(7):e0179783 (IF="2.806," Q2)

(11) Lei Zhang, Xiao-Rui Liu, Jun-Ze Liu, Yu-Xuan Song, Zhan-Qin Zhou, Bin-Yun Cao*, miR-182 selectively targets HOXA10 in goat endometrial epithelium cells in vitro. Reproduction in Domestic Animals, 2017, 52(6):1081-1092. (IF="1.4," Q2).

(12) Lei Zhang#, Xiao-Rui Liu#, Peng Han, Zhan-Qin Zhou, Bin-Yun Cao*, Yu-Xuan Song*. The study of endometrium at gestational days 5 and 15 in dairy goats (Capra hircus). Czech Journal of Animal Science, 62, 2017 (9): 357–368 (IF="0.741," Q2).

(13) L. Zhang#, X. R. Liu#, J. Z. Liu, X. P. An, Z. Q. Zhou, B. Y. Cao, Y. X. Song*. Supplemented Organic and Inorganic Selenium Affects Milk Performance and Selenium Concentration in Milk and Tissues in the Guanzhong Dairy Goat. Biol Trace Elem Res, 2017, 183(2):254-260 (IF="2.399," Q3).

(14) Lei Zhang, YuXuan Song, XiaoRui Liu, JunZe Liu, Li Ma, ZhanQin Zhou, BinYun Cao*. The developmental transcriptome landscape of receptive endometrium during embryo implantation in dairy goats. GENE. 2017, 633: 82-95. (IF="2.415," Q3).

(15) Xiao-Peng An#, Xiao-Rui Liu#, Lei Zhang#, Junze Liu, Xinyan Zhao, Kaiwen Chen, Haidong Ma, Guang Li, Yuxuan Song. MiR-449a regulates caprine endometrial stromal cell apoptosis and endometrial receptivity. Scientific reports. 2017, 7(1):12248. (并列一作，IF=4.2, Q1).

5. 参编著作

（1）羊奶科普知识问答，2020，中国农业出版社（参编）

（1）金昌肉用湖羊养殖技术，2014，金盾出版社（参编）

（2）陕西省职业农民培育丛书——肉羊，2014，三秦出版社（副主编）

6.科研奖励

（1）陕西省优秀博士学位论文，2020年。

（2）肉羊高效养殖关键技术集成与推广，2014年陕西省农业科技推广一等奖。

7.联系方式

通讯地址：陕西杨凌西农路22号 西北农林科技大学动物科技学院

邮编：712100

Email: zhanglei07dongke@163.com